DKK-1 ELISA Kit （BI-20413） 背景简介： DKK-1和Sclerostins是wnt信号通路的有效的抑制剂，且在成骨细胞的分化过程中发挥重要作用。研究表明，骨形成减少、多发性骨髓瘤或由乳腺癌、前列腺癌、肺癌或关节炎引起的骨转移，都可导致DKK-1水平升高。 产品优势： 1）当日即可检测 2）直接测定，不许样品稀释。 3）样本需求量少，只需：20ul 4）标准品范围广 5）充分证实可用于人血清样本检测 6）6个标准品+1个对照（均为血清基质） 7）操作流程简单 试剂盒特点： 1）检测方法：夹心ELISA，HRP/TMB显色系统 2）样本类型：血清 3）样品量：20ul/test 4）标准品范围：0-160 pmol/L 5）检测灵敏度：1.7pmol/L 6）孵育条件：2h/1h/30min 参考文献： 1. Elevated Serum Dickopff-1 Levels Increase Risk of Hip and Vertebral Fracture in Older Caucasian Women. Aarthi Arasu,et al. Endocr. Rev., Jun 2013; 34: SAT-224. 2. Genetic studies on components of the Wnt signalling pathway and the severity of joint destruction in rheumatoid arthritis. Diederik P C de Rooy,et al. Ann Rheum Dis, May 2013; 72: 769 - 775. 3. High dickkopf-1 levels in sera and leukocytes from children with 21-hydroxylase deficiency on chronic glucocorticoid treatment. Giacomina Brunetti,et al. Am J Physiol Endocrinol Metab, Mar 2013; 304: E546 - E554. 4. The Effect of Zoledronic Acid on Serum Dickkopf-1, Osteoprotegerin, and RANKL in Patients with Paget's Disease of Bone. S A Polyzos, et al. Horm Metab Res, Aug 2009 5. Circulating Dickkopf-1 and Radiological Progression in Patients with Early Rheumatoid Arthritis Treated with Etanercept. Patrick Garnero,et al. J Rheumatol, Oct 2008
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